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Kudzu polyphenols decrease hyperinsulinemia and improve glucose control in ob/ob mice
Author(s) -
Peng Ning,
Prasain Jeevan K,
Dai Yanying,
Wyss J. Michael
Publication year - 2010
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.24.1_supplement.1035.8
Subject(s) - kudzu , glycemic , insulin resistance , hyperinsulinemia , puerarin , medicine , insulin , endocrinology , traditional chinese medicine , alternative medicine , pathology
Insulin resistance, impaired glucose handling, hypercholesterolemia, hypertension and obesity contribute to the metabolic syndrome. Recently, there has been a growing interest in the ability of dietary polyphenols to reduce the adverse effects of these factors. Kudzu root extract has a long history of use in traditional Chinese medicine, and our previous studies demonstrate that kudzu root extract provides cardiovascular benefits and improves glycemic and lipid control in spontaneously hypertensive rats. The present study tested whether dietary kudzu root extract also improves glycemic control and hyperinsulinemia in ob/ob mice. Male ob/ob and control mice (2‐month‐old) were placed on a 0.2 % kudzu containing diet or a control diet that was otherwise polyphenol free. After 3 and 8 months on the diets, plasma glucose concentration was lower in kudzu‐treated vs. control mice. Oral glucose tolerance tests (2 g/kg bw) demonstrated that in ob/ob mice dietary kudzu root extract decreased peak elevations in blood glucose (179 [kudzu diet] vs. 273 mg/dl [control diet] increases at 45 minutes). Plasma insulin concentration was lower in kudzu treated compared to control mice. The results indicate that dietary kudzu root extract improves glucose handling in ob/ob mice and suggest that kudzu polyphenols improve insulin resistance in this model.