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Discrepancy between blood flow and tissue‐oxygen in the brain during acute cerebral hypoperfusion in anesthetized rats
Author(s) -
Maruyama Satoshi,
Sato Yoshiaki,
Kemuriyama Takehito,
TandaiHiruma Megumi,
Ohta Hiroyuki,
Manabe Tomoko,
Takahata Tomofumi,
Nishida Yasuhiro
Publication year - 2010
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.24.1_supplement.1033.4
Subject(s) - cerebral blood flow , perfusion , hippocampal formation , blood flow , hippocampus , medicine , cortex (anatomy) , cerebral cortex , anesthesia , chemistry , blood pressure , neuroscience , biology
Acute cerebral hypoperfusion is experienced on head‐to‐foot inertial force (+Gz). However, no report has been found about redistribution of blood flow inside the brain. Then we estimate blood flow (BF) and tissue‐oxygen (PO 2 ) level responses to +Gz stress in the cortex and hippocampus. In 13 male Sprague‐Dawley rats were anesthetized with urethane, cortical and hippocampal blood flows or these PO 2 levels were measured by a laser blood flow meter with the glass fiber prove or a PO 2 monitor with the polarographic oxygen electrodes, respectively. +Gz stress of 3.0 G by a centrifuge decreased arterial pressure at a level of the brain to 39.3 ± 13.5 mmHg, cortical and hippocampal BF to 77.0 ± 17.2% and 66.6 ± 15.1 %, respectively (NS), and these PO 2 to 77.8 ± 14.7 % and 58.9 ± 19.7 %, respectively (p<0.05). After +Gz exposure, PO 2 returned significantly slower than BF in both of the hippocampus and the cortex. These results indicate that acute cerebral hypoperfusion may induce more ischemic damages in the hippocampus than the cortex.