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The possibility of prevention in orthostatic hypotension by water drink
Author(s) -
Abe Chikara,
Tanaka Kunihiko,
Morita Hironobu
Publication year - 2010
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.24.1_supplement.1032.7
Subject(s) - orthostatic vital signs , efferent , baroreflex , pressor response , medicine , anesthesia , blood pressure , heart rate , chemistry , afferent
It is well known that the baroreflex has a significant role in arterial pressure (AP) maintaining during postural change. It is assumed that the AP would decrease during rear up postural change in sinoaortic‐denervated rat, and indeed the AP decreased by 15 ± 1 mmHg during simple rear up in the present study. However, the different AP response was observed in the rear up for water drink: i.e., the AP was increased by 55 ± 7 mmHg. The AP increased and reached to the plateau level during water drink, and then immediately decreased when the rat stopped drinking. This pressor response was not affected by height of water bottle and osmolality of solution. Furthermore, this pressor response was completely abolished by prazosin, and water infusion via the gastric tube did not increase the AP, suggesting that efferent fiber is sympathetic nerve and the afferent receptor might exist in the area from the oral to esophagus. From the present study, it is possible that the orthostatic hypotension can be prevented by water drink.