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Dietary Vitamin A Supplementation Alters Brain Metabolism and Networks Interactions in Mice
Author(s) -
Lane Michelle A,
Riha Penny,
Shumake Jason
Publication year - 2010
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.24.1_supplement.103.7
Subject(s) - interpeduncular nucleus , endocrinology , medicine , ventral tegmental area , vitamin , dorsal raphe nucleus , ventral pallidum , biology , chemistry , central nervous system , serotonin , globus pallidus , serotonergic , basal ganglia , midbrain , dopamine , receptor , dopaminergic
13‐ Cis ‐retinoic acid increases depression‐related behavior and disrupts functional connectivity between the raphe nuclei and hippocampus in mice. Hypervitaminosis A also induces psychosis. The current objective was to determine if dietary vitamin A supplementation alters brain metabolism and neuroanatomical networks. Female nude mice consumed either control (2,400 IU vitamin A/kg diet) or vitamin A‐supplemented (12,000 IU vitamin A/kg diet) diets ad libitum for 5 weeks prior to sacrifice. Cytochome oxidase (CO) histochemistry determined neuronal metabolism. Vitamin A supplementation decreased CO activity in the interpeduncular nucleus and subiculum. Covariant analysis of interregional correlations revealed that vitamin A supplementation caused a functional uncoupling between the ventral tegmental area and lateral habenula and the lateral septal nucleus and infralimbic cortex. Path analysis showed that a network consisting of the interpeduncular nucleus, medial and lateral habenuli and ventral tegmental area was effectively uncoupled in vitamin A‐supplemented mice. These data indicate that excess vitamin A consumption alters brain metabolism and networks. Sponsor: RoAccutane Research Group.