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Enhanced oxidative and carbonyl stress predicts salt sensitivity in obese young adults
Author(s) -
Mori Takefumi,
Kawamata Akihiro,
Hosoya Takuma,
Yoneki Yoshimi,
Mitui Eiko,
Hasegawa Yoko,
Ohta Michi,
Ito Megumi,
Sato Hiromi,
Kabayama Shigeru,
Ito Sadayoshi,
Hida Wataru
Publication year - 2010
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.24.1_supplement.1025.3
Subject(s) - tbars , oxidative stress , medicine , endocrinology , chemistry , lipid peroxidation
Background Methylglyoxal (MGO), a carbonyl substance, is increased in CKD patients and can induce salt sensitive hypertension and insulin resistance together with enhanced oxidative stress in a rat model. The present study determined whether carbonyl/oxidative stress is enhanced in obese young adults and would associate with salt sensitivity. Methods Young adult students (2335students, male:1794, female:541, age:18to28)were enrolled for the study. Daily Na excretion (UNa, as a indicator of Na intake), albumin (UAE, as a marker of CKD), TBARS (U‐TBARS, as a marker of oxidative stress) and MGO (U‐MGO, as a marker of carbonyl stress) was analyzed. Correlations were determined among the parameters in the health checkup. Results Although, SBP, U‐TBARS, U‐MGO and UNa were increased with higher BMI or AC in male students, SBP was increased without increase in U‐TBARS and UNa in high BMI or AC female students. U‐TBARS and U‐MGO had a positive correlation with UNa, and UAE significantly increased with BMI of 30 and above compared to under 30 in either sex. Finally, SBP correlated with BMI of 30 and above in male students while no correlation was observed in those under 30. Conclusion These results indicate that obese has a higher risk of salt sensitive hypertension and CKD in young adults which can be predicted by carbonyl/oxidative stress. Supported by the Grants‐in‐Aid from the Min. of ECSST of Japan (No.20590970)