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Blood pressure independent sexual dimorphism in proteinuric response to high salt intake in Sprague‐Dawley rats.
Author(s) -
Byrd Charlene Abadie,
Rands Vicky F,
Prieto Minolfa C,
Navar L Gabriel
Publication year - 2010
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.24.1_supplement.1024.33
Subject(s) - proteinuria , blood pressure , medicine , sexual dimorphism , endocrinology , body weight , urine , biology , kidney
We examined if changes in blood pressure and proteinuria during chronic salt intake exhibit sex disparities in age‐matched male (♂; N=10) and female (♀; N=10) Sprague‐Dawley (SD) rats subjected to either normal (0.7% NaCl) or high salt (8% NaCl) diets for 2‐weeks. Metabolic studies, systolic blood pressures (SBP) measured by tail‐cuff method and proteinuria in 24‐h urine samples, were performed. Baseline SBP was not different between genders (♂:119.1±3 vs. ♀:119.0±4 mmHg) or after 2‐weeks on HS diet (♂:129.0±5 vs. ♀:125.6±6 mmHg). HS intake induced proteinuria in both sexes; however it was greater in male than in female rats [Day ‐1(♂:5±1 vs. ♀:3±1); Day 9 (♂:36±3 vs. ♀:17±2 mg/day); p<0.01]. By day 13, body weights were higher in ♂ than ♀ rats; however there was no difference with salt load [(male NS: 330±8 versus male HS: 324±7 g); ♀ NS: 217±12 vs. ♀ HS: 226±4 g)]. There were no sex dependent differences in food intake after it factored by body weight (♂ NS: 11±1 g/kg BW; ♂ HS: 12±1 g/kg BW; female NS: 11±2 g/kg BW; female HS: 13±1 g/kg BW; p=no significant). SBP under HS intake did not exhibit sexual dimorphism; however the augmented proteinuria in male rats may reflect a greater predisposition to develop renal injury with high salt consumption than female rats. Grants from the APS (2009 Frontiers in Physiology Research Host Awardees Program); NIH (P20‐RR‐017659; Tulane‐BIRCWH K12HD043451 award).