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Intermittent Hypoxia Causes Pre‐diabetes like Conditions in Rats
Author(s) -
DeLeon Xavier A,
Aguirre Lina,
Colleran Kathleen,
Kanagy Nancy
Publication year - 2010
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.24.1_supplement.1022.8
Subject(s) - intermittent hypoxia , medicine , diabetes mellitus , endocrinology , hypoxia (environmental) , sleep apnea , apnea , insulin resistance , endothelin receptor , hormone , obstructive sleep apnea , receptor , chemistry , organic chemistry , oxygen
Sleep apnea is a common respiratory sleeping disorder characterized by recurring hypoxia and is linked to cardiovascular diseases such as coronary artery disease, heart failure, and hypertension. To model sleep apnea, rats were exposed to intermittent hypoxia (IH) (20 short exposures per hr to 5% O 2 , 5% CO 2 8 hr/day for up to 21 days). We previously reported that 14 days of IH causes endothelin‐dependent hypertension and augments vasoconstrictor sensitivity to endothelin‐1 (ET‐1). In addition, clinical studies suggest a strong association between sleep apnea and diabetes. We therefore performed glucose tolerance tests (GTT) and measured circulating stress hormones to determine if intermittent hypoxia also causes diabetes like conditions in lean rats. We found that after 7 or 14 days of IH, there is no difference in GTT results compared to the same rats at day 0. On day 14, plasma levels of PAI‐1 were not different (Sham vs IH 0.48±0.08 vs 0.94±0.15 ng/ml, p=0.15). Therefore 14 days of IH in healthy, lean rats does not appear to cause insulin resistance or other symptoms of diabetes.