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Anti‐hypertensive action of intermittent hypoxia in young spontaneously hypertensive rats
Author(s) -
Jasti Dinesh,
Manukhina Eugenia,
Willams Arthur,
Howard Linda,
Downey Fred
Publication year - 2010
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.24.1_supplement.1022.4
Subject(s) - intermittent hypoxia , medicine , regimen , obstructive sleep apnea , blood pressure , hypoxia (environmental) , sleep apnea , endocrinology , anesthesia , oxygen , chemistry , organic chemistry
Hypobaric intermittent hypoxia (IH) has been shown to have anti‐hypertensive action, and IH therapy is used clinically to treat hypertensive patients in Eastern European countries. The present study evaluated the effects of normobaric IH on the progression of hypertension in spontaneously hypertensive rats (SHR). Four‐five week old SHR were subjected to either IH (n=15) or to sham IH (n=10). IH rats were exposed for 20 consecutive days to intermittent hypoxia (5 to 8 cycles of 9.5–10 % O 2 , each 5 to 10 min, separated by 4 min normoxia).Sham rats were subjected to the same regimen but with no change in inspired O 2 . Systolic blood pressure (SBP) was measured in all the animals using the tail cuff method (IITC Life Science). Pre‐treatment SBP (mean ± SEM) of IH rats (131 ± 2 mmHg) and sham rats (132 ± 3 mmHg) were similar. After 20 days of IH, SBP of IH rats (162 ± 2 mmHg) was significantly lower (P < 0.001) than that of sham rats (202 ± 3 mmHg). IH associated with sleep apnea is known to cause hypertension. However, the IH regimen of this study, which differs from the IH of sleep apnea, clearly blunted the development of hypertension in young SHR. The anti‐hypertensive mechanism of this regimen of IH merits further investigation.