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HYPOTHALAMIC REGIONS ACTIVATED DURING VOLUNTARY EXERCISE AND AIRPUFF STARTLE
Author(s) -
Dampney Roger,
Lam Alex,
Horiuchi Jouji,
McDowall Lachlan,
Furlong Teri,
Iiigaya Kamon,
Polson Jaimie
Publication year - 2010
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.24.1_supplement.1019.19
Subject(s) - hypothalamus , c fos , medicine , endocrinology , turnover , cardiorespiratory fitness , orexin , chemistry , gene expression , neuropeptide , management , economics , biochemistry , receptor , gene
Both exercise and acute psychological stress are associated with stereotyped cardiovascular and respiratory responses. In this study we used the method of Fos expression to compare the pattern of neuronal activation in the hypothalamus of rats after either voluntary exercise or a mild acute psychological stress (air puff startle). In the exercise group, rats (n=5) had free access to a running wheel. Two hours after the period in which the running activity was maximal (4–6 am), rats were euthanized with an overdose of sodium pentobarbitone, and the brains removed and processed to identify Fos‐positive neurons. Control rats (n=4) were housed without the running wheel. Another group of rats (n=4) were subjected to air puff startle and euthanized 2 hours later. After voluntary exercise there was a marked increase in Fos expression in the hypothalamic perifornical area compared with the dorsomedial hypothalamus (P < 0.05), whereas after air puff startle the reverse was the case (P < 0.05). A high proportion (> 60%) of orexin‐containing neurons in the perifornical area expressed Fos after voluntary exercise. The results suggest that the central mechanisms generating cardiorespiratory responses to stress and exercise may, at least at the level of the hypothalamus, be quite different.