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Chronic increases in dorsal hindbrain (DHB) corticosterone (Cort) enhance the blood pressure response to restraint stress without changing peripheral Cort
Author(s) -
Daubert Daisy L.,
Dong Ying,
Scheuer Deborah A.
Publication year - 2010
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.24.1_supplement.1019.18
Subject(s) - corticosterone , vasopressin , endocrinology , medicine , saline , blood pressure , chronic stress , antagonist , peripheral , chemistry , receptor , hormone
Chronic increases in dorsal hindbrain (DHB) corticosterone (Cort) enhance the blood pressure response to restraint stress without changing peripheral Cort. We tested the hypothesis that blockade of peripheral vasopressin V1 receptors (AVPX) would normalize the blood pressure response to restraint in DHB Cort‐treated rats. DHB 10% Cort or Sham pellets were implanted in male Sprague‐Dawley rats. Blood pressure was measured by radiotelemetry during a control period, 60 min of stress and 30 min post‐restraint on days 6 and 13. A vasopressin antagonist (AVPX, i.v.) was administered on one day, and saline was administered on the other day. Neither DHB Cort nor AVPX altered baseline arterial pressure, which averaged between 97±3 and 101±3 mmHg per group. DHB Cort significantly increased the arterial pressure response to stress and recovery in saline experiments (total integrated increase 1071±59 and 1628±267 mmHg in Sham‐ and Cort‐treated rats respectively, P<0.05). AVPX normalized the arterial pressure response only during the second 30 min of stress in Cort‐treated rats (566±86 and 340±68 mmHg in saline‐ and AVPX‐treated Cort rats respectively, P<0.05), but had no significant effect in Sham‐treated rats. (356±45 and 300±71 mmHg in saline‐ and AVPX‐treated Sham rats respectively). The data suggest that Cort acts in the DHB to recruit vasopressin secretion in response to restraint stress. Funded by NIH grant #HL 076807.