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Regulation of ghrelin production by gastric mTOR signaling
Author(s) -
Zhang Weizhen,
Xu Geyang,
Li Yin,
An Wenjiao,
Mulholland Michael
Publication year - 2010
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.24.1_supplement.1015.5
Subject(s) - ghrelin , endocrinology , medicine , pi3k/akt/mtor pathway , chemistry , hormone , signal transduction , biology , biochemistry
The role of gastric mTOR signaling in ghrelin production and food intake was examined in this study. Here we showed the reciprocal relationship of gastric mTOR signaling and ghrelin during changes in energy status. mTOR activity was down‐regulated, while gastric preproghrelin and circulating total and acyl ghrelin were increased by fasting. In db/db mice, gastric mTOR signaling was enhanced, whereas gastric preproghrelin and circulating total anc acyl ghrelin were decreased. Inhibition of the gastric mTOR signaling by rapamycin stimulated the expression of gastric preproghrelin and ghrelin mRNA, increased the plasma total and acyl ghrelin in both wildtype and db/db mice. Activation of the gastric mTOR signaling by L‐leucine decreased the expression of gastric preproghrelin and the level of plasma total and acyl ghrelin. Ghrelin receptor antagonist D‐Lys3‐growth hormone releasing peptide‐6 abolished the rapamycin‐induced increment in food intake despite that plasma ghrelin remained elevated. mTOR is therefore a gastric fuel sensor whose activity is linked to the regulation of energy intake through ghrelin.