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Sigma1 receptors and neuroblastoma differentiation
Author(s) -
Schrock Joel Michael,
Kim Felix J,
Pasternak Gavril W
Publication year - 2010
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.24.1_supplement.1010.2
Subject(s) - sigma 1 receptor , receptor , neurite , microbiology and biotechnology , biology , sigma receptor , sigma , endoplasmic reticulum , neuroblastoma , in vitro , biochemistry , genetics , cell culture , agonist , physics , quantum mechanics
The sigma 1 receptor is an integral membrane protein of ~26kD which shares no structural homology with any traditional receptor family. Sigma 1 binding sites are highly conserved across mammalian species and are present in a broad range of tissue, with particularly high expression in distinct regions of the CNS. Given the CNS expression of sigma 1 receptors and the neuro‐active properties of many sigma 1 receptor ligands, we hypothesize that sigma 1 receptors may play a role in neuronal differentiation. Differentiating neuroblastoma cells upregulates sigma 1 receptors, with high levels in distinct vesicular structures throughout neurite outgrowths in contrast to an endoplasmic reticulum distribution in undifferentiated cells. These data suggest an association of sigma 1 receptors with neuronal differentiation. Funded by grants to GWP (DA0641, DA02615 and DA00220) from the National Institute of Drug Abuse