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Experimental Validation of a Model of the Arterial Circulation
Author(s) -
Edwards Jonathan William,
Rose William C.
Publication year - 2009
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.23.1_supplement.lb86
Subject(s) - arterial stiffness , blood pressure , cardiology , aortic pressure , biomedical engineering , arterial tree , femoral artery , waveform , medicine , carotid arteries , computer science , telecommunications , radar
Accurate noninvasive measurement of the blood pressure waveforms throughout the body is clinically desirable, but difficult to accomplish. We used a computational model, based on a description of the architecture and mechanical properties of the arterial network and blood, to predict dynamic pressure throughout the arterial vasculature. Applanation tonometry was used to measure dynamic pressure noninvasively at the carotid, radial, and femoral arteries under different conditions. A pressure waveform from one recording site was used as input to the model. Model parameters were adjusted to obtain the best fit between the pressures predicted at other locations and the pressures actually measured at those locations. The site whose pressure was used as the input was altered, and the ability to accurately predict pressures at the other sites was compared. In ten healthy subjects, radial artery pressure allowed most accurate prediction of pressures elsewhere. Vascular stiffness, resistance, and the dependence of stiffness on arterial diameter were determined from the fitted model parameters. The model provides insight into the effects of physiological and pharmacological stimulation on arterial vascular properties in vivo. The model also provides a noninvasive estimate of central aortic pressure, which is valuable for understanding ventricular‐vascular coupling in health and disease.

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