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Metabolic and cardiovascular responses to walking in fructose‐fed male rats
Author(s) -
Machi Jacqueline Freire,
Bernardes Nathalia,
Irigoyen Maria Claudia,
Angelis Kátia,
Wichi Rogério Brandão
Publication year - 2009
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.23.1_supplement.lb74
Subject(s) - medicine , fructose , endocrinology , blood pressure , treadmill , metabolic syndrome , baroreflex , heart rate , chemistry , obesity , biochemistry
The aim of this study was to investigate the metabolic and cardiovascular responses to walking in fructose‐fed male rats. Male Wistar rats were divided into 3 groups (n=6): control (C), sedentary fructose (SF) and walking fructose (100g/L in drinking water at 18 wk) (WF). The walking was performed on a treadmill (1 h/day; 5 days/wk for 8 wk). The arterial pressure (AP) signals were directly recorded (CODAS, 2Khz). Baroreflex sensitivity was evaluated by the tachycardic (TR) and bradycardic (BR) responses induced to AP changes. The tryglicerides concentrations and the insulin tolerance test were performed to evaluate the metabolic profile. The results showed that walking decreased the adipose tissue (SF: 6.5±0.4; WF: 2.8±0.1; C: 3±0.3 g), blood triglycerides level (SF: 291±6.5; WF: 150±8.1; C: 103±4.5 mg/dl) which were observed after fructose overload. The WF group showed increased insulin sensitivity (3.3±0.32 mg/dl/min) compared to SF group (2.5±0.2 mg/dl/min). BR was significantly reduced in WF group (1.95±0.33 vs. 1.40±0.14 bpm/mmhg in SF). However, the walking not changed the increase in AP (SF: 137±2; WF: 129±1; C: 115±6 mmhg). These findings suggest that walking is especially effective for treating the metabolic disturbances. The exercise should be prescribed as appropriate and individualized to be as effective in the management of cardiovascular risk in metabolic syndrome.