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FRUCTOSE OVERLOAD POTENTIATES THE CARDIOVASCULAR AUTONOMIC DYSFUNCTION IN AN EXPERIMENTAL MODEL OF MENOPAUSE AND HYPERTENSION
Author(s) -
Sanches Iris Callado,
Candido Georgia Orsi,
Brito Janaina Oliveira,
Sartori Michelle,
Bernardes Nathalia,
Irigoyen MariaCláudia,
De Angelis Kátia
Publication year - 2009
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.23.1_supplement.lb64
Subject(s) - medicine , endocrinology , baroreflex , ovariectomized rat , blood pressure , menopause , fructose , hormone , heart rate , biology , biochemistry
The objective was to evaluate the effects of ovarian hormone deprivation (9 wks) in hypertensive (or not) female rats submitted (or not) to fructose overload. Female Wistar and SHR rats were divided into (n=7/group): control (C), ovariectomized (bilateral ovarian removal) (O), hypertensive ovariectomized (HO) and submitted to fructose overload (100g/L in drinking water) (FHO). Arterial pressure (AP) was directly recorded. Cardiovascular autonomic control was evaluated by pharmacological blockade and by spectral analysis. The O group showed increased AP and autonomic dysfunction as compared to C group. The FHO group showed increased blood glucose and tryglicerides, insulin resistance; an additional increase in mean AP (174±4 vs. C:108±1; O:121±2; HO:162±5mmHg), resting tachycardia, reduced vagal tonus (5±3 vs. C:55±5; O:37±6; HO:35±7bpm), increased sympathetic tonus (91±18 vs. 39±10bpm in C), decreased high frequency band of the pulse interval (vagal modulation) and exacerbated systolic AP variance and low frequency band (sympathetic modulation) in relation to other groups. The alfa index (baroreflex) was reduced in HO and (further) FHO rats. In conclusion, the fructose overload induced metabolic dysfunctions associated with additional impairment in cardiovascular autonomic control in hypertensive rats submitted to ovarian hormones deprivation. FAPESP: 07/57595‐5, 08/51868‐2; CAPES PROSUP.