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Alternative electrode positioning for monitoring ECG with telemetry in freely moving rats
Author(s) -
Huetteman Daniel Anthony
Publication year - 2009
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.23.1_supplement.lb60
Subject(s) - telemetry , waveform , lead (geology) , software , computer science , ambulatory ecg , signal (programming language) , real time computing , noise (video) , biomedical engineering , coaxial , medicine , simulation , electrocardiography , cardiology , artificial intelligence , telecommunications , geology , image (mathematics) , radar , geomorphology , programming language
Implantable radio‐telemetry allows researchers to collect chronic electrocardiographic (ECG) data from freely moving animals in their home cage. ECG data is typically collected using wire electrodes placed subcutaneously in a lead II configuration. Unfortunately, subcutaneous leads in an ambulatory animal can sometimes be characterized by low signal amplitude, inconsistent waveform characteristics, and high background noise during voluntary muscle movement. These properties can contribute to the inability of researchers to consistently rely on automated software analysis packages to analyze ECG waveforms. This study compares five methods of ECG lead attachment: three using lead II electrode configuration, one previously published base/apex arrangement (Sgoifo, 1996) and a novel trans‐esophageal coaxial ECG lead. The ECG data were analyzed using automated feature detection software (P3P 4.9) and recommendations are presented for optimizing electrode placement for chronic telemetric monitoring of ECG in rats and mice.