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Treatment with eicosapentaenoic and docosahexaenoic acid in vitro increases surface integrin expression in prostate cancer cells
Author(s) -
Bureyko Taylor F,
Dixon Walter T,
Clandinin Tom MT,
Mazurak Vera C
Publication year - 2009
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.23.1_supplement.lb519
Subject(s) - lncap , docosahexaenoic acid , eicosapentaenoic acid , integrin , prostate cancer , chemistry , cell adhesion , cancer research , cell , biochemistry , cancer , biology , fatty acid , polyunsaturated fatty acid , medicine
Prostate cancer cells typically metastasize to bone, a process facilitated by integrin adhesion receptors. Modulation of integrin expression represents an important therapeutic opportunity, however, mechanisms of integrin regulation are not fully understood. The objective of this study was to measure total and surface integrin expression in a series of prostate cancer cell lines in response to n‐3 fatty acid treatment. Prostate cancer cell lines representative of increasing stages of malignancy (RWPE‐1