Premium
Serum antioxidant capacity in head and neck cancer patients receiving chemoradiation therapy.
Author(s) -
Hine R Jean,
Prior Ronald L,
Gardner Kenneth E,
Maddox Anne Marie,
Siegel Eric R.,
Stack Brendan C,
Vural Emre A,
Suen James Y.
Publication year - 2009
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.23.1_supplement.lb512
Subject(s) - oxygen radical absorbance capacity , antioxidant , antioxidant capacity , head and neck cancer , medicine , radiation therapy , cancer , chemistry , pharmacology , biochemistry
Measurements of in vivo antioxidant capacity might help to resolve a controversy about the safety of antioxidant supplements during concurrent chemoradiation therapy for cancers of the head and neck. Some data suggest that antioxidant supplements chemoradiation therapy may reduce treatment toxicities; other evidence indicates they may protect tumor cells from oxidative damage. The study defined serum antioxidant capacity before, during and after outpatient therapy. Total, hydrophilic and lipophilic oxygen radical absorbance capacity was measured in serum using the ORAC FL microplate method. The procedure is based on the inhibition of peroxyl radical‐ induced oxidation initiated by thermal decomposition of azo‐compounds using fluorescein as the fluorescent probe. The median age of the subjects (n=27) was 58. Forty four percent took supplements. Most were smokers and reported smoking during therapy. Quantifying antioxidant intakes was complicated by treatment toxicities. Total (P=0.0081) and hydrophilic (P=0.0222) antioxidant capacity declined significantly between the pretreatment and end of radiation visits; no changes were detected in the lipophilic fraction. There was, however, marked interindividual variability in the temporal patterns of the lipophilic fraction. To our knowledge, this is the first report of antioxidant capacity in cancer patients receiving similar treatments.