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Effect of decaffeinated coffee on the serum glucose and insulin responses elicited by oral glucose
Author(s) -
Matusheski Nathan V.,
Wolever Thomas M. S.,
Black Richard M.
Publication year - 2009
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.23.1_supplement.lb452
Subject(s) - crossover study , insulin , medicine , glycemic , endocrinology , caffeine , insulin sensitivity , meal , diabetes mellitus , glycemic index , area under the curve , insulin resistance , alternative medicine , pathology , placebo
A large amount of epidemiologic evidence has emerged indicating an association of coffee consumption with decreased risk for type‐2 diabetes. However, pure caffeine may acutely decrease insulin sensitivity. We conducted a randomized controlled crossover study to determine the effect of an Arabica and Robusta blend decaffeinated coffee (DC), administered either before or concurrently with 75g oral glucose (OGTT), on serum glucose and insulin responses. Ten healthy subjects were studied on 4 separate occasions after overnight fasts. DC was consumed with an OGTT (DC0), or 30min (DC‐30) or 60min (DC‐60) before the OGTT, or not at all (Control). Water was consumed 30min before the OGTT in the control treatment. The incremental area under the curve (AUC) for glucose after DC‐60 was similar to control, but significantly less than that after DC0. There were no differences in insulin response between treatments. An insulin sensitivity index based on fasting glucose and insulin concentrations (HOMAr) at 0 min tended to be less (p=0.052) on DC‐60 compared to DC0. These results suggest that proximity to a meal may influence the effect of decaffeinated coffee on glycemic response. Additional research should examine whether Arabica and Robusta coffee sources possess similar efficacy.