Premium
The relationship of serum phospholipids fatty acid composition with metabolic syndrome and cardiovascular disease risk in Korean adults
Author(s) -
Kim Bumsik,
Park JY,
Kim JY,
Paik JK,
Ordovas JM,
Lee JH
Publication year - 2009
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.23.1_supplement.lb450
Subject(s) - metabolic syndrome , medicine , polyunsaturated fatty acid , fatty acid , endocrinology , biochemistry , obesity , chemistry
This study aimed to determine whether fatty acid (FA) composition in serum phospholipids affects metabolic syndrome (MetS) and cardiovascular disease (CVD) risk in Korean adults aged at least 20 years. 722 adults were recruited. 116 adults of them met MS criteria (American Heart Association/National Heart, Lung, and Blood Institute, 2005). To examine CVD risk, we measured PWV by an automatic waveform analyzer (model VP‐1000; Nippon Colin Ltd., Komaki, Japan). Serum phospholipids FAs were measured by gas‐liquid chromatography. Compared with subjects without MetS, those with MetS had higher 18:1 n9, 20:3 n6 and lower 18:2 n6, 20:0, 22:1, 24:0 (p<0.05). PWV was significantly higher in MetS than normal adults (p<0.01). PWV was associated positively with 16:0, 20:3 n6, 22:0, Saturated FA (p<0.05). In contrast, it was associated negatively with 12:0, 18:2 n6, 20:0, PUFA, n6 FA (p<0.05). These results show that MetS may increase CVD risk by influencing FA metabolism, especially, increase of 20:3 n6 and decrease of 18:2 n6 and 20:0.