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Methanol extract of gromwell has anti‐obesty effect in obese (DIO, ob/ob) mice
Author(s) -
Park Jin Kyung,
Chon Jeong Woo,
Lee Mi Ae,
Hwang EunJoo,
Park Yoo Kyoung
Publication year - 2009
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.23.1_supplement.lb422
Subject(s) - triglyceride , medicine , endocrinology , leptin , lipolysis , chemistry , adipose tissue , body weight , obesity , cholesterol
The effect of methanol extract of gromwell in inducing weight loss in obese mice was assayed. DIO mice were induced with a high fat diet (45%) for 10 weeks. After 10 weeks of dietary manipulation, gromwell extracts [LGR (100 mg/ kg/day) and HGR (300 mg kg/day)] was administered by gavages for 10 weeks. After 10wks, the body weight of gromwell groups was reduced LGR (16.21%), HGR (11.46%) as compared with the control. Leptin of gromwell groups were significantly decreased compared with the control. The mRNA level of PPARγ, SREBP‐1c, SCD‐1 and NPY of gromwell groups was significantly increased than control. Second, ob/ob mice were treated gromwell extract with 100 (LGR) or 300 mg/kg/day (HGR) as previously described. Body weight gain was reduced in gromwell groups (18.65%, 19.36%) as compared with the control. Also gromwell groups were significantly reduced liver, epididymal adipose tissue weight than control. In fasted serum and level of total cholesterol (TC), triglyceride (TG), glucose and hepatic TC, TG on gromwell groups were significantly lower compared with the control, while HDL‐c were significantly higher than control (p<0.05). Gromwell improved positive energy state for homeostasis in genetically obese mice. Further research will be focused on exploring the detailed mechanisms by which extract of gromwell exerts effect on lipolysis pathways in obese mice.