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LIPIDS PROFILE IS THE MOST INFLUENTIAL CARDIOVASCULAR RISK FACTOR ON THE OXIDATIVE STRESS IN A GENERAL HUMAN POPULATION.
Author(s) -
Cuevas Santiago,
Roman Elena,
Lopez Bernardo,
Hernandez Isabel,
Carbonell Luis F
Publication year - 2009
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.23.1_supplement.lb40
Subject(s) - oxidative stress , myeloperoxidase , malondialdehyde , body mass index , population , medicine , risk factor , c reactive protein , physiology , blood pressure , inflammation , endocrinology , environmental health
Aim Oxidative stress and inflammation appear to play an important role in the process of ageing and in the associated dysfunction of the human cardiovascular system. In this study we tried to identify which of the cardiovascular risk factors are better related with oxidative stress, in a human population with a wide range of age. Methods The study population included subjects (n=160; age range: 18‐84 years) living in the metropolitan area of Murcia (Spain). It were measured general blood biochemical variables, arterial blood pressure and anthropometrical data, as well as plasma concentration of the oxidative stress and inflammation markers, myeloperoxidase (MPO, EIA), C‐reactive protein ultrasensitive (hsCRP; EIA), and malondialdehyde (MDA; HPLC). It were also collected information about personal habits of the subjects (tabaquism, alcohol and diet). Interactions between variables were calculated by correlation (Pearson or Spearman) and multiple regression analyses. Results CRP, MPO and MDA were associated to trigliceryds and/or total cholesterol. Multiple regression tests indicated that body mass index was the most influential factor on the lipids variables. Conclusion To higher blood concentration of triglycerides and total cholesterol more oxidative stress and inflammation in a general human population. Body mass index may be a good marker of this association.