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Therapeutic Effect of Ginkgo Biloba Extract on Rat Heart Failure Induced by Isoprenaline
Author(s) -
Yi Hongwei,
Wang Yongqing,
Ding Fuyun,
Meng Ling,
Wu Xudong
Publication year - 2009
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.23.1_supplement.lb377
Subject(s) - isoprenaline , metoprolol , heart failure , medicine , ginkgo biloba , chemistry , creatine kinase , endocrinology , pharmacology , stimulation
Objective To investigate the effect of Ginkgo biloba extract (GBE) on rat heart failure induced by isoprenaline and its mechanism. Methods The SD rat heart failure was induced by isoprenaline administrated subcutaneouly for 11 days. 100 mg/kg/d GBE and 10 mg/kg/d Metoprolol were pretreated 3 days before isoprenaline. The index of haemodynamics and serum contents were detected. Results Isoprenaline increased the heart index and left ventricle index significantly, but GBE and Metoprolol could alleviate rat myocardial hypertrophy. GBE had stronger effect on inhibition of the increase in AST and LDH than Metoprolol; on the contrary, Metoprolol was more potential for decreasing creatine kinase, MB isoenzyme of creatine kinase and hydroxybutyrate dehydrogenase level. Isoprenaline decreased the level of LVSP, LVEDP, LV +dp/dt max and LV ‐dp/dt max and increased heart rate. Metoprolol and GBE blocked the effects of isoprenaline respectively, but there is not significant difference between GBE and Metoprolol. GBE and Metoprolol inhibited the increase in mRNA levels of AMP‐activated protein kinase alpha 1, 2 and ryanodine receptor 1 induced by isoprenaline significantly. Conclusion GBE attenuated the damage of cardiac muscle, improved the dysfunction of rat heart induced by isoprenaline. Not like Metoprolol, a beta receptor blocker, GBE exerts a different mechanism in curing heart failure.