Premium
Maternal diabetes suppresses intrauterine kidney growth in male but not female ACI rats
Author(s) -
Lane Pascale H,
Commers Tessa,
Shull James D
Publication year - 2009
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.23.1_supplement.lb29
Subject(s) - offspring , medicine , endocrinology , kidney , litter , pregnancy , nephron , urinary system , gestation , diabetes mellitus , biology , physiology , genetics , agronomy
Maternal diabetes (MDM) increases the risk of kidney abnormalities in offspring. The ACI rat has a 10‐15% risk of renal anomalies, especially aplasia, in normal pregnancy, but the effects of MDM in this strain is unknown. Female ACI rats received streptozocin or buffer, and MDM was confirmed 2‐3 days later by glucose measurement. Females were then housed with males until pregnancy was confirmed. Blood glucose was monitored every 3 days throughout gestation. After delivery, pups were studied for kidney anomalies and weight on day 3‐5 of postnatal life. Litter size and sex distribution were similar regardless of MDM, as was the rate of renal agenesis. Pup weight was reduced with MDM in males (8.3±0.2 vs 7.0±0.4g; p<0.01) but not in females (7.8±0.3 vs 7.5±0.4g). Kidney weight also showed sex‐specific reductions with MDM. MDM has been shown to reduce kidney weight and nephron number in rats, but the interaction of pup sex and MDM has not been previously described. Given interactions between reproductive and urinary structures in embryogenesis, sex‐specific problems are not surprising. Further study is needed to determine if this phenomenon occurs in other rat strains or if this is particular to the ACI rat.