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Effect of impact exercise on skeletal muscle and bone in OI model mice
Author(s) -
Weber Bettina Anne,
Ferreira J. Andries,
Carleton Stephanie,
McCambridge Amanda,
Phillips Charlotte,
Brown Marybeth
Publication year - 2009
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.23.1_supplement.lb170
Subject(s) - osteogenesis imperfecta , connective tissue , endocrinology , procollagen peptidase , skeletal muscle , chemistry , anatomy , medicine , pathology
Osteogenesis imperfecta (OI) is a heritable connective tissue disorder in which mutations in type I procollagen genes result in bone deformity and fragility. The OI model mice ( oim / + ) are heterozygous for a null mutation in the COL1A2 gene of type I collagen and have reduced bone biomechanical integrity compared to wild type (WT) mice. Bone is inherently mechanosensitive, responding and adapting to its mechanical environment. Bone formation occurs in response to high mechanical loads; often changing its geometry to strengthen the skeleton. The largest physiological loads bones typically experience are from muscles. We postulate that even though the OI bone material is biomechanically weaker, the bone will respond to muscle loading, especially during pubertal growth to generate an inherently stronger bone. In a small pilot study, we characterized the muscle mass and contractile generating capacity of non‐exercised and exercised oim /+ mice. We found that therapeutic inclusion of impact exercise can lead to an increase in the contractile generating capacity of the gastrocnemius and soleus muscles as well as bone biomechanical integrity. This knowledge is important in our ultimate understanding of muscle and bone function in OI model mice and ultimately, humans with this disease.