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A short‐term free‐fall landing enhances local bone formation without showing of woven bone
Author(s) -
Lin HsinShih,
Huang Tsang Hai,
Yang Ai Lun,
Mao Shih Wei,
Tai Yuh Shiou,
Yang Rong Sen
Publication year - 2009
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.23.1_supplement.lb14
Subject(s) - apposition , ground reaction force , medicine , bone remodeling , statistical analysis , orthodontics , anatomy , mathematics , physics , kinematics , statistics , classical mechanics
Objective The purpose of this study was to investigate the effects of a mechanical loading course (free‐fall landing) on local bone metabolism. Methods Thirty‐two female Wistar rats (7‐week‐old) were randomly assigned into three groups, which were the L30 (n=11), L10 (n=11) and CON (n=10) groups. Animals of the L30 and L10 group underwent 5‐day free fall landing from a height of 40cm for 30 and 10 times per day, respectively. Landing ground reaction force (GRF) was recorded on day 1 and day 5. Methods of dynamic histology, tissue geometric and biomaterial measurements were performed on animals' ulnae. One‐way ANOVA was used for statistical analysis. When statistical significance was shown (p<0.05), pair‐wise comparisons were made using the Fisher's LSD method. Results In dynamic histological analysis, no ulna revealed formation of woven bone in all animals. Periosteal as well as endosteal mineral apposition rate (MAR, μm/day) was significantly higher in L30 group as compared to the CON group. And, periosteal bone formation rate per unit of bone surface (BFR/BS, μm 2 /μm 3 /year) was significantly higher in the L10 and L30 groups. Conclusions In conclusion, a 5‐day free‐fall landing training produce a slight but significant higher bone formation on ulnae of female young rats. As compared with other mechanical loading models, this free‐fall landing revealed no signs of damages (no woven bone formation) to landing site and would be a more realistic model to mimic mechanical stimulus induced by various physical activities. Grant supported from the National Science Council (NSC‐94‐2314‐B‐006‐033, Taiwan).