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Effects of endurance running training and diet control on bone development and metabolism in young male rat
Author(s) -
Chang MingYao,
Huang TsangHai,
Yang AiLun,
Lin CheFu,
Lin HsinShin
Publication year - 2009
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.23.1_supplement.lb12
Subject(s) - bone remodeling , endurance training , medicine , bone mineral , treadmill , endocrinology , histology , zoology , biology , osteoporosis
Objective The aim of this study was to investigate how endurance running and diet control affect growing bone. Methods Forty‐eight male Wistar rats (7 weeks old) were randomly assigned into four groups, which were control group (CON, n=12), high intensity running group (HIGH, n=12), low intensity running group (LOW, n=12), and diet control group (DCON, n=12). Animals in the High and Low groups underwent treadmill running 5 days/week for 8weeks. The DCON rats received mean quantity of chow consumed by exercise groups. Blood and bone samples were collected and stored for further analysis of serum marker, dynamic histology and geometry. Results After an eight‐week exercise training, body weight gain of the CON group was significantly higher than other three groups. Regarding dynamic histology assay, MS/BS (mineral surface/bone surface) did not show difference among groups. The CON group was numeric but not significantly higher in long bone cross‐sectional parameters. Tibiae length were higher in the CON group than other groups ( p <.05). Serum calcium, phosphorus and insulin‐like growth factor‐I (IGF‐I) was significant lower in the DCON group ( p< .05). Conclusions 1) Similar to human studies, endurance running rats showed equal or somewhat lower values in bone tissue measurements, but no negative results revealed on bone turnover. 2) Diet control might cause an un‐equivalent physiology status in non‐exercise rats, which may not be appropriate to be set as a normal control group. Grant supported by National Science Council (NSC‐97‐2410‐H‐006‐083‐MY2, Taiwan).