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Modeling of gender differences in respiratory function during exercise using Quantitative Human Physiology
Author(s) -
Carter Cory Blake,
Hodnett Benjamin Lucas,
Hester Robert
Publication year - 2009
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.23.1_supplement.lb118
Subject(s) - respiratory system , respiratory physiology , physiology , respiratory exchange ratio , medicine , exercise physiology , human physiology , cardiology , heart rate , blood pressure
Quantitative Human Physiology (QHP) is an open‐source XML model of human physiology based on Quantitative Circulatory Physiology (QCP), a previous model created to incorporate over 4000 simultaneous equations. The QHP model has been expanded to include a female (F) subject, allowing investigation of gender differences on human physiology. For this model, respiratory function was examined in a 78‐kg male (M) subject and a 60‐kg F subject. The protocol involved having the subjects perform 30‐min treadmill exercise protocol (2% incline at 2 miles/hour) and comparing respiratory parameters to pre‐exercise conditions. Respiratory parameters were analyzed as percent increases, due to the different baseline parameters between the M and F subjects. Pre‐exercise alveolar ventilation (Va) for M and F was 4.4 L/ min and 3.5 L/min, respectively. Following 30 min of exercise, M Va increased 305% whereas F Va increased 394% (Figure). Interestingly, post‐exercise Va was similar between the M and F (17.8 L/min vs. 17.3 L/min). This model will investigate the physiological mechanisms underlying these differences in respiratory function between M and F, including the role of differences in pulmonary blood flow and blood gas exchange. Supported by NSF EPSCoR and NIH # HL‐51971.