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Influences of pregnancy on the core temperature response to ip TNF[alpha] in rats
Author(s) -
Fewell James Edwin,
LiuTertil Limin
Publication year - 2009
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.23.1_supplement.lb112
Subject(s) - tumor necrosis factor alpha , hypothermia , endocrinology , lipopolysaccharide , medicine , core temperature , antipyretic , thermoregulation , cytokine , pregnancy , interleukin 6 , inflammatory response , alpha (finance) , chemistry , immunology , inflammation , pharmacology , biology , nursing , analgesic , patient satisfaction , genetics , construct validity
Pregnant (P) rats exhibit hypothermia in response to doses of E. coli LPS that elicit fever in nonpregnant (NP) rats. In NP rats, LPS elicits significant increases in plasma concentrations of IL‐1β, IL‐6, IL‐1ra and TNFα whereas in P rats, LPS elicits significant increases in antipyretic/cryogenic cytokines (i.e., IL‐1ra & TNFα) but not in pyrogenic cytokines (i.e., IL‐1β & IL‐6). The present experiments were carried out on 58 NP and 56 near‐term P chronically‐instrumented and conscious rats to investigate the influence of pregnancy on the core temperature (Tc) responses to i.p. TNFa. In NP rats, doses of TNFa ranging from 0.1 to 1000 µg/kg produced significant increases in Tc (i.e., fever). In P rats, however, TNFa did not elicit fever but produced hypothermia in doses of 10µg/kg and greater. Thus, our data provide insight into the possible role that TNFα plays in mediating the differential Tc response to LPS in NP and P rats.