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Increased BNP during Myocardial Injury Decreases Gastric Emptying and Gastrointestinal Absorption
Author(s) -
Addisu Anteneh,
Gower William R.,
Dietz John R.
Publication year - 2009
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.23.1_supplement.983.1
Subject(s) - medicine , gastric emptying , ventricle , myocardial infarction , ejection fraction , endocrinology , natriuretic peptide , cardiology , heart failure , stomach
We have shown that B‐type Natriuretic peptide (BNP) decreases gastric emptying and absorption in mice. We examined whether acute myocardial injury which releases BNP also affects gastric emptying and absorption. Wild‐type (WT) and NPR‐A receptor knockout (KO) mice were anesthetized with isoflurane. A 2 mm incision was made between the 4th and 5th intercostal space and a probe cooled in liquid nitrogen applied directly to the left ventricle to induce cryo‐infarction. In WT mice, gastric emptying (%) one week after MI was 68 ± 6 vs. 89 ± 3 in sham (n=5, P<0.05). Two weeks after MI, emptying was 82 ± 1 vs. 98 ± 1, MI vs. sham (n=5, P<0.05). Absorption, (relative plasma fluorescence) was 350 ± 79 vs. 632 ± 121; (n=6, P< 0.05) MI vs. sham. KO mice showed no significant difference in emptying or absorption. Echocardiography showed left ventricular (LV) ejection fraction of 48 ± 3 vs. 64 ± 2 % (P<0.05), fractional shortening of 24 ± 2 vs. 35 ± 2 % (P<0.01), LV systolic volume (μl) of 51 ± 7 vs. 26 ± 3 (P<0.05), LV posterior wall thickness (mm) of 0.76 ± 0.10 vs. 1.15 ± 0.10 (P<0.05), MI vs. sham respectively. BNP levels (pg/ml) were 4292 ± 276 one week after MI vs. 105 ± 11 in sham (n=5, p<0.05). BNP levels were 1965 ± 755 two weeks after MI, (n=5, p<0.05). Conclusions Elevated plasma BNP following acute myocardial injury decreases gastric emptying and absorption in mice. (Support: VA Merit Award to William R. Gower Jr. & NSF/IGERT, Grant to A. Addisu)