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Tranilast protects from renal injury in streptozotocin‐induced diabetic Dahl salt sensitive rats
Author(s) -
Hosoya Takuma,
Mori Takefumi,
Ohsaki Yusuke,
Yoneki Yoshimi,
Nakamichi Takashi,
Nagasawa Tasuku,
Sato Hiroshi,
Ito Sadayoshi
Publication year - 2009
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.23.1_supplement.971.6
Subject(s) - streptozotocin , endocrinology , medicine , diabetic nephropathy , tbars , excretion , oxidative stress , diabetes mellitus , chemistry , lipid peroxidation
The present study was designed to investigate the role of tranilast (TL), which inhibits TGF‐beta, in the renal injury and oxidative stress of streptozotocin (STZ)‐induced diabetic Dahl salt sensitive (Dahl S) rats and compared to the insulin (INS) treatment. Dahl S rats were administered with STZ (65mg/kg)(STZ), STZ with TL (400mg/kg/day) (STZ+TL), STZ with INS (10U/kg/day) (STZ+INS), or STZ with INS and TL (STZ+INS+TL). Urinary albumin and TBARS excretion was analyzed as a marker of renal injury and oxidative stress, respectively. Blood glucose level of STZ and STZ+TL groups (572.83±37.3, 639.71±27.5 mg/dl) were significantly higher than those of STZ+INS and STZ+INS+TL groups (330.83±61.39, 221.14±83.41 mg/dl). Systolic blood pressure was increased in all groups, but did not have difference between groups. Urinary albumin excretion was significantly decreased in STZ+TL group (43.6±6.3 mg/day) and STZ+INS group (41.7±7.1 mg/day) compared to STZ group (76.5±6.9 mg/day), and further decrease in STZ+INS+TL group (24.6±3.1 mg/day). Reduction in urinary TBARS excretion was observed only in STZ+INS group compared to STZ group. These results indicate that tranilast protects from renal injury independent of blood pressure, blood glucose level and oxidative stress in diabetic Dahl S rats.