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Altered renal hemodynamic and excretory function in rats treated with a COX2 inhibitor during the nephrogenic period
Author(s) -
Reverte Virginia,
Saez Fara,
Salazar Francisco,
Llinas Maria T,
Salazar F. Javier
Publication year - 2009
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.23.1_supplement.969.12
Subject(s) - excretory system , endocrinology , renal function , medicine , kidney , hemodynamics , blood pressure , excretion , renal physiology , nephron
The administration of a COX‐2 inhibitor during the perinatal period (COX2 Inh‐pp) reduces nephron number by 17%, and leads to the development of hypertension. However, there are important gender differences in the aging‐dependent renal structural changes in COX2 Inh‐pp‐treated rats. Our objective was to examine whether the renal response to an amino acid (aas) infusion, and the renal excretory response to an acute volume expansion (AVE) are altered in COX2 Inh‐pp‐treated rats. Newborn SD rats were treated with vehicle or a COX2 Inh‐pp (Rofecoxib, 2.4 mg/kg/day). The responses to aas infusion or to AVE (6%, bw) were examined at 3 months of age in male and female rats treated with vehicle or the COX2 Inh‐pp. No changes in arterial pressure were found in any group during the experiments. An increase (P<0.05) in GFR (47%), RPF (28%) and sodium excretion (152%) was found in vehicle‐treated males in response to aas. However, this renal hemodynamic and excretory response to aas was completely abolished in COX2 Inh‐pp‐treated males. The renal response to aas was also prevented in COX2 Inh‐pp‐treated females. The renal excretory ability to eliminate an AVE was also reduced in male (28%, P<0.05) and female (38%, P<0.05) COX2 Inh‐pp‐treated rats. Our results demonstrate that the COX2 inhibition during the perinatal period leads to an important impairment of the renal hemodynamic and excretory function during the adult age.

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