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Beneficial cardiac effects of enalapril in postmenopausal hypertensive rats
Author(s) -
Zilberman Judith Miriam,
Yañes Licy L,
Tomat Analia,
Romero Mariana,
SartoriVallinoti Julio,
Elesgaray Rosana,
costa Maria A,
Reckelhoff Jane F,
Arranz Cristina
Publication year - 2009
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.23.1_supplement.968.11
Subject(s) - endocrinology , medicine , enalapril , oxidative stress , chemistry , lipid peroxidation , glutathione peroxidase , estrogen receptor , tbars , renin–angiotensin system , estrogen , angiotensin converting enzyme , ovariectomized rat , blood pressure , catalase , cancer , breast cancer
Several studies suggest an interaction between renin‐angiotensin system and estrogen with nitric oxide (NO) system and oxidative stress. Objective: To evaluate the effects of the angiotensin‐converting enzyme inhibitor enalapril (E) on systolic blood pressure (SBP), oxidative stress, NO synthase (NOS) activity and estrogen receptors expression in the left ventricle (LV) of postmenopausal spontaneously hypertensive rats (OF‐SHR). aged 16 month received E 250 mg/L in drinking water or tap water (C) for 30 days. At the end of the treatment lipid peroxidation end products (TBARS), estrogen receptors expression, catalase (CAT), glutathion peroxidase (GPx) and NOS activity were measured in LV. Results Treatment with enalapril decreased SBP and lipid peroxidation but increased GPx and NOS activity in OF‐ SHR. Estrogen receptor β was upregulated by E treatment in LV of OF‐SHR. * p<0.02 vs control, #p<0.01 vs control. In conclusión, our study shows that enalapril administration caused a reduction in oxidative stress and increases in NOS activity and estrogen receptor βexpression in LV of OF‐SHR. These results suggest that changes observed in the LV after menopause may be Angiotensin II mediated.