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Neonatal induced mild diabetes: influence on rat development and behavioral activity
Author(s) -
Kiss Ana Carolina Inhasz,
Sinzato Yuri Karen,
Spada Ana Paula Machado,
Bueno Aline,
Iessi Isabella,
Sakamoto Silvia,
Saito Felipe,
Kempinas Wilma De Grava,
Rudge Marilza Vieira Cunha,
Damasceno Débora Cristina
Publication year - 2009
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.23.1_supplement.962.7
Subject(s) - streptozotocin , medicine , endocrinology , diabetes mellitus , anogenital distance , open field , body weight , fetus , pregnancy , biology , in utero , genetics
The aim was at evaluating the effect of neonatal mild diabetes induced by streptozotocin on development and behavioral activity of female Wistar rats. At birth, 81 female rats were randomly assigned into two groups: Control (n=20) received citrate buffer (subcutaneous route ‐ sc.) and STZ (n=61) received streptozotocin (STZ ‐ 100 mg/kg ‐ sc.). Glycemia was measured at postnatal days (PND) 35, 84 and 120. Physical development was daily evaluated. At PND 10 and 21, body weight (g), length (cm), and anogenital distance (mm) were measured and anogenital index was obtained. Behavioral activity was evaluated in an open field at PND 10, 21 and 75. Streptozotocin administration in the neonatal period of Wistar rats caused mild hyperglycemia in adulthood with no effects on physical development, although resulting in reduced body length and anogenital distance. Rats with mild hyperglycemia intensity (STZ group) also presented reduced locomotor and exploratory behavior, which are similar to the results presented in behavioral studies of severe diabetic rats. These data showed that even a modest hyperglycemia is enough to impair behavioral activity. Financial support by Capes.