Premium
PHYSICAL (IN)ACTIVITY AND GLUTAMATE RECEPTOR ACTIVATION IN THE ROSTRAL VENTROLATERAL MEDULLA OF SPONTANEOUSLY HYPERTENSIVE RATS
Author(s) -
Mancini Eric J.,
FlackValdez Amanda B.,
Mueller Patrick J.
Publication year - 2009
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.23.1_supplement.958.10
Subject(s) - rostral ventrolateral medulla , medicine , glutamate receptor , endocrinology , glutamatergic , sympathetic nervous system , blood pressure , receptor , heart rate
A sedentary lifestyle is a major risk factor for hypertension. Treatment of hypertension with regular exercise can be beneficial if prescribed appropriately. Hypertension is associated with sympathetic overactivity and excessive glutamatergic excitation of the rostral ventrolateral medulla (RVLM). We have reported that sedentary versus physically active conditions enhance sympathoexcitation elicited from the RVLM in otherwise "normal" rats. We hypothesized that sedentary conditions may also enhance sympathoexcitation elicited from the RVLM of spontaneously hypertensive rats (SHRs). To test this hypothesis, RVLM microinjections were performed in Inactin anesthetized SHRs that remained sedentary or were physically active (running wheels; 8‐10 wks; 7.9±0.5 km/day). Preliminary data suggest that mean arterial pressure and lumbar sympathetic nerve responses to glutamate (1‐100mM) varied over time and responses to AMPA (1‐10μM) and NMDA (1‐100μM) also differed over time in both sedentary and physically active SHRs. These preliminary data support the possibility of glutamate receptor mediated alterations in the RVLM of hypertensive rats under both physically active and sedentary conditions. These potential mechanisms may be involved in the development of hypertension in sedentary individuals, and in the treatment of hypertension with exercise prescription. (AHA‐0650161Z)