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High sucrose diet impact on voluntary wheel running prevents obesity in rats
Author(s) -
Scarpace Erin T,
Tumer Nihal
Publication year - 2009
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.23.1_supplement.955.6
Subject(s) - sucrose , calorie , obesity , caloric intake , dietary sucrose , turnover , endocrinology , medicine , chemistry , zoology , food science , biology , management , economics
Two important factors contributing to energy balance are caloric intake and physical activity. One form of volitional activity is voluntary wheel running (WR). The extent of WR diminishes with age and obesity. We examined the impact of a high fat (HF) (60% kcal, fat; 7% kcal, sucrose, 5.24 kcal/g) and a high sucrose (11% fat; 60% sucrose, 4.07kcal/g) diet on WR over 12 weeks compared with a chow diet (4% fat; 7% sucrose, 3.41kcal/g). The HF fed rats ate the most calories during the first week, with the high‐sucrose fed consuming more than controls, but less than HF fed rats. All rats consumed similar amounts of calories for the remaining 11 weeks, and overall cumulative caloric consumption was unchanged across groups. Only the HF fed rats became progressively obese. The rats in all groups ran progressively less over the 12 weeks with a 36% decrease in chow (p<0.012), a 37% decrease in the HF (p<0.032), and a 12.9% decrease in the high sucrose (p<0.018). Those on the high‐sucrose diet had the smallest decrease in running (p<0.035). In summary, voluntary WR declined progressively over 12 weeks on all diets, but decrease was least in the rats consuming the high‐sucrose diet. This higher level of physical activity may explain why these rats did not become obese, compared with the HF fed, despite consuming a similar amount of calories. Supported by Medical Research Service, Dept of Veterans Affairs and NIH AG026159.