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Short‐term aerobic exercise training decreases Glucagon‐like Peptide‐1 in obese individuals
Author(s) -
Baynard Tracy,
Carhart Robert L,
Kanaley Jill A
Publication year - 2009
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.23.1_supplement.955.5
Subject(s) - medicine , aerobic exercise , endocrinology , incretin , insulin , glucagon , glucagon like peptide 1 , type 2 diabetes , hormone , meal , obesity , diabetes mellitus
Glucagon‐like peptide 1 (GLP‐1) is a relatively new incretin hormone secreted by the gut and is associated with appetite regulation and satiety. It is actively under study as a therapy for obesity and diabetes, yet the effects of exercise on this hormone are unknown. Objective To determine if a short‐term training period would influence GLP‐1 in obese individuals. Methods Sedentary, obese individuals (n=17; 51 yrs; body mass index 33.8 kg/m 2 ) underwent 10 continuous d of exercise training. Training consisted of treadmill walking for 1 h/d at 75% of peak aerobic capacity. GLP‐1, glucose tolerance (2 hr meal test; 2 cans of Ensure(tm)) and aerobic capacity were assessed pre and post‐training. Results Body weight did not change with training, but peak aerobic capacity improved (24.1 ± 1.7 vs. 26.0 ± 1.8 mL/kg/min; p<0.05). Fasting insulin concentrations decreased (41.6 ± 5.3 vs. 31.0 ± 2.9 pmol/L; p<0.05), while glucose tolerance was unchanged (glucose AUC). GLP‐1 decreased by 27% following training (3.01 ± 0.32 vs. 2.20 ± 0.22 pmol/L; p<0.05). The change in fasting insulin was correlated to the change in GLP‐1 (r = 0.97; p<0.001). Conclusions Aerobic exercise training appears to elicit early changes in the gut hormone, GLP‐1, in obese persons. This may be an important mechanism by which exercise improves glucose tolerance and insulin sensitivity independent of changes in skeletal muscle. Research support: NIH R21 DK063179 (JAK); Sigma Delta Epsilon Fellowship; American College of Sports Science Mid‐Atlantic Chapter.