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Chronic resistance training attenuates age‐associated endothelial dysfunction in coronary arteries of aging rats
Author(s) -
Araj Christina A.,
Richards Margaret A.,
Harris M. Brennan
Publication year - 2009
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.23.1_supplement.955.27
Subject(s) - medicine , coronary arteries , cardiology , endothelial dysfunction , bradykinin , coronary flow reserve , vascular resistance , bolus (digestion) , resistance training , coronary circulation , blood flow , endocrinology , hemodynamics , artery , receptor
Age is associated with reduction endothelial‐dependent vasorelaxation in human and animal coronary arteries. Endurance exercise training has been shown to reverse this and to protect against myocardial ischemia/reperfusion in isolated rat hearts in part through improved coronary flow. Although resistance exercise training may be prescribed in aged individuals to enhance quality of life, little is known regarding the effects of this type of exercise on coronary endothelial function. Therefore, aged (24 mo) male, Fisher 344 rats were divided into two groups: Aged Sedentary (AS, n=8), and Aged Trained (AT, n=10). Resistance exercise training consisted of climbing a 1 m wire ladder, at an 85 o angle, 3d/wk for 7 weeks with increasing weight added to the tail. Coronary flow was measured in isolated, perfused hearts using the Langendorff model and constant pressure. After a 30 minute stabilization period, changes in coronary flow were measured following bolus injections of bradykinin (BK, 10 −12 ‐10 −4 ) using an in‐line flow meter. Coronary flows were significantly (P<0.05) improved at high doses of BK in AT versus AC. In conclusion, these results suggest that resistance exercise training in aged rats attenuates age‐associated endothelial dysfunction in coronary arteries. Supported by NIH R15 HL082649‐01 (MBH) and the Borgenicht Program for Aging Studies and Exercise Science (MBH).