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Exercise effectiveness for atrophic muscle in estrogen (E2) replete and ovariectomized (OVX) female rats
Author(s) -
Ferreira J Andries,
Hemmann Kaitlyn M,
Brown Marybeth
Publication year - 2009
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.23.1_supplement.955.24
Subject(s) - ovariectomized rat , estrogen , medicine , atrophy , endocrinology , hindlimb , skeletal muscle , gastrocnemius muscle , muscle atrophy , soleus muscle , muscle mass
Studies suggest that women who are E2 deficient do not respond to exercise as well as women who are E2 replete. PURPOSE determine if differential recovery occurs in atrophic skeletal muscle in OVX rats, with and without E2 and with and without exercise. METHODS 78 female rats age 5 mos were randomly placed into 6 groups: 1) control, 2) Hindlimb unweighted 4 weeks (HLU), 3) recovery no E2, 4) recovery + E2, 5) exercise no E2, 6) exercise + E2. Recovery groups cage recovered or were exercised daily for 14 days after HLU. RESULTS HLU resulted in significant atrophy and loss of muscle force (p<0.05) in soleus, plantaris, gastrocnemius, tibialis anterior. Return of muscle mass toward control levels occurred in both cage ambulation but not both exercise groups. Exercise + E2 was more effective than exercise without E2. Representative muscle mass/body mass ratio data and Po are given for gastrocnemius (mean ± sem). Exercise was effective for E2 supplemented rats but not for rats that were E2 deficient. Exercise without E2 rats had histological evidence of damage (central nuclei). CONCLUSIONS Exercise + E2 appears to be the most effective stimulus for the recovery of atrophic muscle, whereas exercise without E2 may be detrimental. Support: NIH HD058834 , Spinal Injuries Research Board, Research Council at Univ. of Missouri