Premium
Hypogonadal Male Runners Do Not Display Endocrine or Performance Decrements during Prolonged Endurance Exercise
Author(s) -
HewButler Tamara Dawn,
Jordaan Esme,
Noakes Timothy D,
Soldin Steven J,
Verbalis Joseph G
Publication year - 2009
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.23.1_supplement.955.14
Subject(s) - endocrine system , testosterone (patch) , medicine , endocrinology , hormone , physiology
Study aims 1) determine if hypogonadal male runners exhibit an impaired performance or endocrine response 2) determine which endocrine factors influence testosterone in male runners Design 58 males participating in ultramarathon plus 2 lab trials with 10 subjects Results The only statistically significant difference in any measured parameter between eugonadal versus hypogonadal men was [androstenedione] p Δ(61.9 vs. 98.9 ng/dl). Statistically significant linear correlations noted between [testosterone] p Δ versus: [NT‐proBNP] p Δ(r = 0.41) and [AVP] p Δ(r = ‐0.38). Significant positive correlations noted between age versus: [testosterone] p Δ(r = 0.41) and finish time (r = 0.31) but not pre‐race [testosterone] p . [NTproBNP] pΔ , age, [AVP] pΔ , [cortisol] pΔ , urine osmolality Δand pre‐race [testosterone] p accounted for 68% of the variance noted in post‐race [testosterone] p in nonrecursive pathway diagrams. Conclusions Low testosterone levels in male marathoners were not associated with decrements in performance or endocrine‐stress response. Collective clusters of endocrine and/or non‐endocrine factors ‐ such as age, BNP, AVP and cortisol ‐ perhaps should be assessed in tandem when considering therapeutic options aimed at male hypogonadism. Research support Astellas Pharma US, Inc., Deerfield, IL and by Grant M01RR‐023942‐01 from the National Center for Research Resources (NCRR)