Premium
Physical Activity Reduces Prostate Carcinogenesis in a Transgenic Model
Author(s) -
Esser Karyn,
Harpole Clifford,
Prins Gail,
Diamond Alan
Publication year - 2009
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.23.1_supplement.955.1
Subject(s) - prostate cancer , prostate , tramp , carcinogenesis , medicine , genetically modified mouse , cancer , physical activity , animal model , transgene , physiology , oncology , endocrinology , pathology , cancer research , biology , physical therapy , gene , biochemistry
Several epidemiological studies have reported an inverse association between physical activity and the risk of prostate cancer. In general, as exercise intensity increased in the rats/mice, the likelihood that physical activity inhibited carcinogenesis increased. In order to establish an animal model to investigate the effects of physical activity on prostate cancer development, the present study used C3(1)Tag mice that are predisposed to prostate cancer due to the directed expression of SV40 oncogenes combined with voluntary wheel running exercise. The results presented indicate that prostatic cancer progression is likely delayed or diminished by wheel running in a dose dependent manner. Mice that ran > 5Km/group exhibited 83% of the dorsolateral prostates as within normal levels for pathology vs. 43% for the < 5 km/day group (p=0.16). In addition, the pathologic progression to high‐grade PIN and local invasion, considered to be an early event in the formation of prostate adenocarcinoma, was significantly reduced with increased running. Forty three percent of dorsolateral prostates from mice that ran less than 5 km/day were classified with advanced pathology as compared to none in mice that ran more than 5.0 km/day (p=0.05). These findings provide further evidence that exercise acts to decrease the progression of prostate cancer and they establish a transgenic animal model for future mechanistic studies.