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Myostatin inhibition enhances the effects of exercise on performance and metabolic outcomes in aged mice
Author(s) -
LeBrasseur Nathan K,
Schelhorn Teresa,
Bernardo Barbara,
Loria Paula,
Brown Thomas A
Publication year - 2009
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.23.1_supplement.954.8
Subject(s) - medicine , endocrinology , basal metabolic rate , myostatin , basal (medicine) , sed , insulin , skeletal muscle
The objective of this study was to investigate the effects of 4 weeks of exercise training (Ex), myostatin inhibition (MyoI) and Ex+MyoI on performance and metabolic outcomes in 24‐month old mice. At study termination no differences were noted in body weight or composition by computed tomography, however, the mean weight of quadriceps muscles were 17% greater in MyoI mice relative to vehicle (Veh) (p < 0.01). In performance measures, Ex+MyoI mice demonstrated a > 2‐fold increase in treadmill running time and distance compared to Veh (both p < 0.001) and both Ex and Ex+MyoI groups demonstrated increased habitual activity compared to Veh (p < 0.05). No differences were observed in grip strength or nerve‐evoked peak tetanic force; however, all treatment groups demonstrated >30% reductions in muscle fatigue relative to Veh in elicited contractions (all p < 0.01). In metabolic measures no differences were observed in glucose tolerance but Ex and Ex+MyoI demonstrated significantly greater reductions in basal glucose in response to an insulin bolus compared to Veh. Increased oxygen consumption and basal metabolic rate were also demonstrated by MyoI and Ex+MyoI mice relative to Veh (all p < 0.05). These data suggest that combining exercise training with a pharmacological strategy to increase muscle mass may confer significant improvements upon both physical function and whole body metabolism in older individuals.