Premium
Proteinuria is associated with increased systemic and glomerular water permeability
Author(s) -
Ferguson Joanne K,
Neal Chris R,
Bates David O,
Harper Steven J,
Salmon Andrew H J
Publication year - 2009
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.23.1_supplement.950.14
Subject(s) - proteinuria , medicine , endocrinology , renal function , oncotic pressure , endothelial dysfunction , kidney , urology , albumin
Proteinuria is associated with an increased risk of cardiovascular death. Evidence suggests that proteinuria reflects systemic endothelial dysfunction as well as renal pathology. The Munich Wistar Fromter (MWF) rat strain develops spontaneous proteinuria, permitting study of altered endothelial function under conditions of increased proteinuria. Male MWF rats (15‐24 wks) were significantly proteinuric (MWF:15.0±1.5 n=14 Wistar: 1.8±0.20 n=10, p<0.0001). Hydraulic conductivity ( L p ) and effective oncotic pressure (σ δπ ) were measured in individually perfused microvessels of the mesentery. Male MWF rats had significantly increased L p (x10 −7 cm s −1 cmH 2 0 −1 ) but unchanged σ δπ (cmH 2 0) compared with age matched wistar controls ( L p MWF:6.4±1.8 n=7; Wistar: 2.8±0.4 n=15, p<0.05 σ δπ MWF:24.6±2.0 n=7; Wistar:23.7±0.9 n=7). Normalised glomerular ultrafiltration coefficient ( L p A / V i ) was measured using an oncometric assay. The increase in systemic L p was mirrored by a significant increase in glomerular L p A / V i (MWF: 1.5±0.1 min −1 mmHg −1 n=58; Wistar: 1.0±0.1 min −1 mmHg −1 n=24, p<0.01). These results suggest proteinuria is associated with increased glomerular and systemic water permeability. The mechanistic links require further investigation and may provide insight into the predictive link between proteinuria and increased cardiovascular mortality. Supported by BHF