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Anti‐diabetic and anti‐inflammatory effects of an aqueous extract of Ligustrum japonicum in db/db mice with type 2 diabetes
Author(s) -
Lee An Sook,
Kang Dae Gill,
Lee Ho Sub
Publication year - 2009
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.23.1_supplement.939.19
Subject(s) - endocrinology , medicine , diabetic nephropathy , creatinine , diabetes mellitus , kidney , triglyceride , inflammation , renal function , cholesterol
We investigated the effect of an aqueous extract of Ligustrum japonicum (ALJ) in db/db mice with type 2 diabetes. The mice were treated orally with aqueous extract of Ligustrum japonicum (300 mg/day/kg) for 10 weeks to examine the long‐term effects on hyperglycemia and glomerular histology as well as biochemical and functional abnormalities in kidney. As the results, we found that ALJ treatment markedly reduced hyperglycemia (p<0.01), plasma triglyceride, and plasma creatinine in diabetic db/db mice. Furthermore, treatment of ALJ significantly increased plasma level of high density lipoprotein (HDL)‐cholesterol, urine osmolality, and ameliorated creatinine clearance (Ccr) in diabetic db/db mice. We also found that overexpressions of vascular cellular adhesion molecule (VCAM)‐1 and endothelin (ET)‐1 were observed in aortic tissue of db/db mice, ALJ suppressed both expression of VCAM‐1 and ET‐1 in aorta. In kidney glomerular, the glomeruli enlargement and TGF‐β1 overexpression also found in db/db mice, ALJ significantly decreased those levels. Thus, based on our finding, ALJ could reduce hyperglycemia, vascular inflammation and prevent the development of diabetic nephropathy.