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Effect of ethanol extract of Cynanchum wilfordii on vascular dysfunction in rat fed high fat diet
Author(s) -
Choi Deok Ho,
Kim Eun Ju,
Lee An Sook,
Kang Dae Gill,
Lee Ho Sub
Publication year - 2009
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.23.1_supplement.939.17
Subject(s) - sodium nitroprusside , medicine , endocrinology , triglyceride , chemistry , hyperlipidemia , aorta , endothelial dysfunction , cholesterol , vasodilation , nitric oxide , diabetes mellitus
Hyperlipidemia and hypercholesterolemia are critical pathogenic factors for the development and maintenance of atherosclerosis. This study was designed to investigate whether the ethanol extract of Cynanchum wilfordii (ECW) suppresses atherogenesis in rat fed with high fat diet (HFD). Treatment of HFD with low (100 mg/day/kg) or high (200 mg/day/kg) doses of ECW for 8 weeks markedly attenuated plasma level of triglyceride (TG) and augmented plasma level of high density lipoprotein (HDL)‐cholesterol. Treatment of ECW also lowered the systolic blood pressure (SBP) in atherogenic diet rats. Furthermore, the impairment of acetylcholine (ACh)‐ and sodium nitroprusside (SNP)‐induced relaxation of aortic rings in the HFD‐rat was improved by chronic treatment of ECW. Treatment of ECW also suppressed the HFD‐induced increase in expression levels of intracellular cell adhesion molecule (ICAM)‐1, vascular cellular adhesion molecule (VCAM)‐1, and E‐selectin as well as matrix metalloproteinase (MMP)‐2 in aorta. The decrease in production of cGMP induced by HFD was recovered by administration with ECW in aortic tissue. Taken together, the present study suggests that ECW prevents vascular inflammatory process and vascular dysfunction in rat fed high fat diet.