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Pharmacological Probes for AMPA Receptors
Author(s) -
England Pamela M.
Publication year - 2009
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.23.1_supplement.92.2
Subject(s) - ampa receptor , neuroscience , ion channel linked receptors , long term potentiation , synaptic plasticity , long term depression , silent synapse , receptor , glutamate receptor , neurotransmission , biology , excitatory postsynaptic potential , metaplasticity , chemistry , biochemistry , inhibitory postsynaptic potential
Alpha‐amino‐3‐hydroxy‐5‐methyl‐4‐isooxazolepropionic acid (AMPA) receptors are a family of glutamate‐gated ion channels that mediate the majority of fast, excitatory synaptic transmission in the mammalian central nervous system. In addition, changes in the efficacy of AMPA receptor mediated synaptic responses underlie many forms of normal plasticity (e.g. long‐term potentiation and memory). Moreover, AMPA receptors have been implicated in several neuropathologies (e.g. schizophrenia and Alzheimer's disease). Changes in the expression pattern of AMPA receptors may provide a molecular basis for both normal and maladaptive forms of plasticity. Data describing the development and use of novel pharmacological tools for studying the activity of AMPA receptors will be presented.