Premium
Immunomodulatory effect of Avian 3000 in chickens
Author(s) -
Lohani Madhukar,
Maurice Denzil,
Scott Thomas
Publication year - 2009
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.23.1_supplement.907.14
Subject(s) - immune system , broiler , spleen , glycoprotein , blood proteins , significant difference , biology , zoology , medicine , immunology , endocrinology , biochemistry
Our study evaluated the immunomodulatory and performance properties of a nanotechnology‐based product Avian 3000® administered in drinking water to broilers. In this field trial, 48 broilers were selected from grower farms representing control and treated groups. Body and organ weights, feathering score, leg score, and bone density were the performance indicators. The immune response was assessed by measurement of serum alpha‐1‐acid glycoprotein (AGP), IgG, IgA and IgM concentrations. Statistically significant differences were not detected in any of the performance variables measured but among the organ weights, spleen weights approached significant difference between the two groups of broilers. Serum IgG and alpha‐1‐ acid glycoprotein concentration were found to be higher in the treated as compared to the untreated (P< 0.0003 and P<0.03, respectively) but serum IgM concentration was higher (P< 0.01) in the untreated birds. The groups did not differ in serum IgA (P>0.65) and total serum protein (P>0.11). The results indicate that Avian 3000® has immunomodulatory properties in chickens and controlled experiments are needed to reproduce and expand the findings.