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Growth and body composition in low‐body weight rats: influence of dietary fat
Author(s) -
Suarez Cristina,
Ferreira Andrea,
Macri Vanesa,
Ramos Cecilia,
Gonzales Chaves Macarena,
Pellegrini Gretel,
Rodriguez Patricia,
Zeni Susana,
Friedman Silvia
Publication year - 2009
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.23.1_supplement.903.6
Subject(s) - body weight , weaning , composition (language) , zoology , medicine , endocrinology , chemistry , biology , philosophy , linguistics
Previous studies demonstrated the relationship between dietary fat and body composition. However, we studied the hypothesis that body weight (BW) of the infant, would influence body composition. At weaning female Wistar rats (n=70) were grouped according to BW (aged=21 day) as follows: control (C, n=31) >33.5 g BW and experimental (E, n=35) <33.5 g BW. C received a diet containing 7% w/w of fat (AIN‐G) and E was fed one of 2 diets; E 1 (n=20), fat=7% w/w (AIN‐G) and E 2 (n=15), fat=15% w/w. At aged 28, 35 and 49 (t 28 , t 35 and t 49 , respectively), 8 rats per group were sacrificed. BW and % body fat and total skeleton body mineral content (BMC) by DEXA (Lunar DPX‐L) were evaluated. Body gain velocities (BGV) within times were calculated. BMC was analyzed per BW −0.75 . Results (mean±SD) assessed by ANOVA and Dunnett test. At t 28 and t 35 , C BW was higher than E (p<0.001) despite BGV in E groups was increased as compared to C (p<0.001). From t 35 , only E 1 showed higher BGV (p<0.01). Body fat % and BMC/ BW −0.75 did not show significant differences throughout experimental period. Conclusion: We speculate that in low‐body weight individuals, dietary fat equal to RDA may be insufficient to achieve body size proportions, leading to a delayed in growth rate; meanwhile % body fat and BMC related to BW −0.75 appears to be in proportion to BW. Awarded by UBACyT O 004 and O015.