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Survey of biological active molecules in the Chinese traditional herbal formula Liu Wei Di Huang Wan for the treatment of Type II Diabetes
Author(s) -
Mao Sena,
Chuang G.,
Tam W.,
Tam G,
Tam Chick
Publication year - 2009
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.23.1_supplement.900.5
Subject(s) - rehmannia glutinosa , catalpol , traditional medicine , herb , glycoside , scrophulariaceae , chemistry , botany , traditional chinese medicine , medicine , biology , medicinal herbs , alternative medicine , pathology
Objective Identify biological active molecules in the ancient herbal formula Liu Wei Di Huang Wan (LWDHW) to treat diabetes in China. Methods Handbook of Active Constituents from Chinese Materia Medica & Phytomedicine (ISBN: 9620731549) by Wing and Gen. Result LWDHW (aka Rehmannia Six) is consist of six herbs: Rehmannia glutinosa (Shou Di Huang), Dioscorea opposita (Shan Yao), Poria cocos (Fu Ling), Paeonia moutan (Mu Dan), Cornus officinalis (Shan Zhu Yu) and Alisma plantago (Ze Xie). The emperor herb Rehmannia glutinosa contains jionoside A1 & B1, jiocarotenosides, four iridoid glucosides (catalpol, leonuride, aucubin, and melittoside); and four glycosides (rehmannioside A, B, C, and D) from the roots of species of var. purpurea and hueichingensis; glycosides (desrhamnosyl acteoside, forsythiaside, purpureaside A and B) from the leaves of species of Digitalis purpurea; and glycosides (purpureaside A & B & C, ateoside) from the callus of the same species. LWDHW improves hyperglycemia and increases insulin sensitivity. Conclusion LWDHW has the bioactive function for the treatment of diabetes based on Traditional Chinese Medicine (TCM).