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Nutritional status and intake post nutritional supplementation in prostate cancer patients undergoing radiotherapy
Author(s) -
Bartalone Rachel Leigh,
Tyrpak Donna,
Browne Richard W.,
Wilding Gregory E.,
Horvath Peter J.,
Brown Jean K.
Publication year - 2009
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.23.1_supplement.898.13
Subject(s) - micronutrient , medicine , vitamin c , placebo , dietary reference intake , nutritional supplementation , vitamin , vitamin e , medical nutrition therapy , prostate cancer , endocrinology , cancer , physiology , antioxidant , nutrient , chemistry , biochemistry , alternative medicine , organic chemistry , pathology
Patients undergoing radiation therapy show decreased appetite, declining nutritional intake and status. The use of dietary supplementation during therapy has been questioned. To examine this effect, 53 prostate cancer patients were assigned to 3 groups (Placebo, DRI ‐ Dietary Reference Intake levels of vitamins/minerals, or OM ‐ Orthomolecular levels of antioxidants were added to DRI ‐Vitamin C, E, Se, and Carotenoids). Blood, body measures, and 3 day diet/activity records were collected at baseline and 3 times during supplementation ‐ before, during, post therapy. Energy imbalance increased with Placebo due to increasing energy expenditure and decreasing energy intake (from a decrease in carbohydrate and sugar intake), but not with DRI and OM. Before supplementation, micronutrient intake was generally below DRI levels and stayed low with Placebo. After DRI and OM, 95% of subjects reached DRI intakes, except Vitamin D and A (50 and 75%, respectively). Only plasma vitamin C increased with DRI. After OM; plasma vitamin C, alpha‐tocopherol, beta‐carotene and lycopene increased (80, 110, 160, and 40%, respectively), while lutein did not increase significantly. Energy balance was more negative over therapy without supplementation, due to increased activity and a decreased carbohydrate intake. The negative energy balance increase may be due to lack of micronutrient intake combined with radiation therapy. Grant Funding Source NCI/NIH 5R21CA102391‐2